03/02/2014
Inflammation and chronic pelvic pain: a biological trigger for depression in women?
Graziottin A. Skaper S. Fusco M.
Inflammation and chronic pelvic pain: a biological trigger for depression in women?
Journal of Depression & Anxiety, 2013, 3, 1, 1000142. doi:10.4172/2167-1044.1000142
CONDIVIDI SU
Chronic inflammation, pain and depression are a clinical triad increasingly recognized as co-morbid. Peripheral and central inflammation can alter neuronal activity, thereby contributing to the psycho-emotional and somatic symptoms of depression. Preliminary evidence suggests that mast cells direct the immune pathways mediating this triad.
The present review analyzes current evidence on co-morbidity between depression with peripheral and central inflammation associated with chronic pelvic pain in women. The analysis will briefly focus on key mechanisms of inflammation and role of mast cells as a common denominator of depression and chronic pain. The goal is to offer mental health professionals a biologically oriented contribution in the pathophysiologic reading of co-morbidities between depression and chronic pelvic pain in women.
top
Keywords:
Anxiety
- Comorbidity
- Depression
- Neuropathic Pain
- Chronic Pelvic Pain
- Inflammation
- Mastcells
© 2014 - Alessandra Graziottin Foundation
FAIR USE: The content of this paper can be downloaded, printed and read for strictly personal and non-profit use. Any citation for didactic and/or scientific purpose must quote the title of the document, the name of the author(s), the data of the book or journal, and the URL of the site (www.fondazionegraziottin.org).
WARNING: Every therapy must be discussed, tailored, prescribed and monitored by the M.D. personally consulted. Every information presented in this website can not surrogate the personal relationship with the caring physician nor be utilized without specific medical advice.
